Version 5.4
Homo sapiens Gene: SLC1A3
Summary
InnateDB Gene IDBG-16618.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC1A3
Gene Name solute carrier family 1 (glial high affinity glutamate transporter), member 3
Synonyms EA6; EAAT1; GLAST; GLAST1
Species Homo sapiens
Ensembl Gene ENSG00000079215
Encoded Proteins
IDBP-16620
solute carrier family 1 (glial high affinity glutamate transporter), member 3
IDBP-16622
solute carrier family 1 (glial high affinity glutamate transporter), member 3
IDBP-364847
solute carrier family 1 (glial high affinity glutamate transporter), member 3
IDBP-483799
solute carrier family 1 (glial high affinity glutamate transporter), member 3
IDBP-484127
solute carrier family 1 (glial high affinity glutamate transporter), member 3
IDBP-475827
solute carrier family 1 (glial high affinity glutamate transporter), member 3
IDBP-809092
solute carrier family 1 (glial high affinity glutamate transporter), member 3
IDBP-809093
solute carrier family 1 (glial high affinity glutamate transporter), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a member of a high affinity glutamate transporter family. Mutations in this gene are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:36606355-36688334
Strand Forward strand
Band p13.2
Transcripts
ENST00000265113 ENSP00000265113
ENST00000381918 ENSP00000371343
ENST00000416645 ENSP00000414078
ENST00000513903 ENSP00000427203
ENST00000512374
ENST00000504121
ENST00000506725
ENST00000505202 ENSP00000424986
ENST00000513646 ENSP00000420992
ENST00000502864
ENST00000514563
ENST00000509272
ENST00000505376
ENST00000506178
ENST00000612708 ENSP00000483657
ENST00000613445 ENSP00000477672
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005314 high-affinity glutamate transmembrane transporter activity
GO:0005515 protein binding
GO:0016595 glutamate binding
GO:0016597 amino acid binding
GO:0017153 sodium:dicarboxylate symporter activity
Biological Process
GO:0001504 neurotransmitter uptake
GO:0006536 glutamate metabolic process
GO:0006537 glutamate biosynthetic process
GO:0006811 ion transport
GO:0006835 dicarboxylic acid transport
GO:0007268 synaptic transmission
GO:0007605 sensory perception of sound
GO:0009416 response to light stimulus
GO:0009449 gamma-aminobutyric acid biosynthetic process
GO:0009611 response to wounding
GO:0015813 L-glutamate transport
GO:0021545 cranial nerve development
GO:0031223 auditory behavior
GO:0042493 response to drug
GO:0046677 response to antibiotic
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050806 positive regulation of synaptic transmission
GO:0050885 neuromuscular process controlling balance
GO:0051938 L-glutamate import
GO:0055085 transmembrane transport
GO:0070779 D-aspartate import
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043205 fibril
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005360
View Gene Order
ENSBTAG00000018245
Not yet available
Pathways
NETPATH
REACTOME
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_13639
Astrocytic Glutamate-Glutamine Uptake And Metabolism pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_13594
Neurotransmitter uptake and Metabolism In Glial Cells pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.481918 Hs.592840
RefSeq NM_001166695 NM_001289939 NM_001289940 NM_004172 XM_005248342 XM_006714488
HUGO
OMIM
CCDS CCDS3919 CCDS54844
HPRD 02523
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca