InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC1A3

Summary

InnateDB Protein

IDBP-16622.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC1A3

Protein Name

solute carrier family 1 (glial high affinity glutamate transporter), member 3

Synonyms

EA6; EAAT1; GLAST; GLAST1;

Species

Homo sapiens

Ensembl Protein

ENSP00000371343

InnateDB Gene

IDBG-16618 (SLC1A3)

Protein Structure

UniProt Annotation

Function

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Episodic ataxia 6 (EA6) [MIM:612656]: A disorder characterized by episodic ataxia, seizures, migraine and alternating hemiplegia. {ECO:0000269PubMed:16116111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0001504	neurotransmitter uptake
GO:0006811	ion transport
GO:0006835	dicarboxylic acid transport
GO:0007268	synaptic transmission
GO:0051938	L-glutamate import
GO:0055085	transmembrane transport
GO:0070779	D-aspartate import