Version 5.4
Mus musculus Protein: Cma1
Summary
InnateDB Protein IDBP-166282.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cma1
Protein Name chymase 1, mast cell
Synonyms Mcp-5; Mcp5; Mcpt5; MMCP-5;
Species Mus musculus
Ensembl Protein ENSMUSP00000022834
InnateDB Gene IDBG-166280 (Cma1)
Protein Structure
UniProt Annotation
Function Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Subcellular Localization Secreted {ECO:0000269PubMed:1527387}. Cytoplasmic granule {ECO:0000269PubMed:1527387}. Note=Secretory granules.
Disease Associations
Tissue Specificity Mast cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0042277 peptide binding
Biological Process
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0030901 midbrain development
GO:0045766 positive regulation of angiogenesis
GO:0050720 interleukin-1 beta biosynthetic process
GO:0071333 cellular response to glucose stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0030141 secretory granule
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID MGI:96941
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P21844
PhosphoSite PhosphoSite-
TrEMBL A4QPC5
UniProt Splice Variant
Entrez Gene 17228
UniGene
RefSeq NP_034910
MGI ID
MGI Symbol Cma1
OMIM
CCDS CCDS27135
HPRD
IMGT
EMBL AC163646 AF119364 BC139454 BC139457 BC139759 CH466535 M68898 M73759 M73760 X68805
GenPept AAA39492 AAA40105 AAD43901 AAI39455 AAI39458 AAI39760 CAA48705 EDL36225

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca