InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cma1

Summary

InnateDB Gene

IDBG-166280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cma1

Gene Name

chymase 1, mast cell

Synonyms

Mcp-5; Mcp5; Mcpt5; MMCP-5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022225

Encoded Proteins

IDBP-166282

chymase 1, mast cell

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24257755

[Homo sapiens] Mast cell chymase CMA1 contributes to the control of inflammation by degrading the virulence factor Hsp70 of Trichinella spiralis, as well as several alarmins such as endogenous HSPA1A, BGN, and HMGB1..

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092009:
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:55941453-55944661

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022834

ENSMUSP00000022834

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0042277	peptide binding

Biological Process

GO:0006508	proteolysis
GO:0006518	peptide metabolic process
GO:0030901	midbrain development
GO:0045766	positive regulation of angiogenesis
GO:0050720	interleukin-1 beta biosynthetic process
GO:0071333	cellular response to glucose stimulus