InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC2A3

Summary

InnateDB Protein

IDBP-16635.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC2A3

Protein Name

solute carrier family 2 (facilitated glucose transporter), member 3

Synonyms

GLUT3;

Species

Homo sapiens

Ensembl Protein

ENSP00000075120

InnateDB Gene

IDBG-16633 (SLC2A3)

Protein Structure

UniProt Annotation

Function

Facilitative glucose transporter. Probably a neuronal glucose transporter.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in brain. Expressed in many tissues. {ECO:0000269PubMed:3170580}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005355	glucose transmembrane transporter activity
GO:0022857	transmembrane transporter activity
GO:0022891	substrate-specific transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006810	transport
GO:0008645	hexose transport
GO:0015758	glucose transport
GO:0019852	L-ascorbic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002666 Reduced folate carrier
IPR002945 Glucose transporter, type 3 (GLUT3)
IPR003663 Sugar/inositol transporter
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF01770
PF00083
PF07690

PRINTS

PR01192
PR00171

PIRSF

PIRSF028739

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt