InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Senp7

Summary

InnateDB Protein

IDBP-166406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Senp7

Protein Name

SUMO1/sentrin specific peptidase 7

Synonyms

2410152H17Rik; 2810413I22Rik; 2900036C23Rik; 6030449K19Rik; AI790676; mKIAA1707;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086779

InnateDB Gene

IDBG-166404 (Senp7)

Protein Structure

UniProt Annotation

Function

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full- length SUMO proteins to their mature forms (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0008150	biological_process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:1913565

InterPro

IPR003653 Peptidase C48, SUMO/Sentrin/Ubl1

PFAM

PF02902

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BUH8

PhosphoSite

PhosphoSite-Q8BUH8

TrEMBL

UniProt Splice Variant

Entrez Gene

66315

UniGene

Mm.398052

RefSeq

NP_079759

MGI ID

MGI Symbol

Senp7

OMIM

CCDS

CCDS28222

HPRD

IMGT

EMBL

AK085060 AK122542 BC058593

GenPept

AAH58593 BAC39352 BAC65824