InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irgm1

Summary

InnateDB Protein

IDBP-166427.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irgm1

Protein Name

immunity-related GTPase family M member 1

Synonyms

Ifggd3; Ifi1; Iigp3; Iipg3; Irgm; LRG-47;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050446

InnateDB Gene

IDBG-166425 (Irgm1)

Protein Structure

UniProt Annotation

Function

Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion. {ECO:0000269PubMed:11457893, ECO:0000269PubMed:14576437, ECO:0000269PubMed:14707092, ECO:0000269PubMed:15607973, ECO:0000269PubMed:15908352, ECO:0000269PubMed:16339555, ECO:0000269PubMed:17911638, ECO:0000269PubMed:17982087, ECO:0000269PubMed:19920210}.

Subcellular Localization

Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Late endosome membrane. Cell projection, phagocytic cup. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing phagosomes. Association with phagosomes is dependent on nucleotide-binding but is IFNG-independent. Preferentially associated with cis- and medial-Golgi. Also detected in late endosomes and lysosomes.

Disease Associations

Tissue Specificity

Expressed in lung and primary macrophages. {ECO:0000269PubMed:14576437}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005525	GTP binding
GO:0016817	hydrolase activity, acting on acid anhydrides

Biological Process

GO:0006914	autophagy
GO:0006952	defense response
GO:0008152	metabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0000139	Golgi membrane
GO:0000421	autophagic vacuole membrane
GO:0001891	phagocytic cup
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0031902	late endosome membrane
GO:0042995	cell projection