Version 5.4
Mus musculus Gene: Irgm1
Summary
InnateDB Gene IDBG-166425.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irgm1
Gene Name immunity-related GTPase family M member 1
Synonyms Ifggd3; Ifi1; Iigp3; Iipg3; Irgm; LRG-47
Species Mus musculus
Ensembl Gene ENSMUSG00000046879
Encoded Proteins
IDBP-166427
immunity-related GTPase family M member 1
IDBP-201809
immunity-related GTPase family M member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21731484
Irgm1 is responsible for the IFN-gamma mediated induction of the antimicrobial defence system against Chlamydia trachomatis in mouse. Irgm1/Igtp knockout mice develop high bacterial burden post intrauterine infection, but subsequently clear the infection more efficiently than wt mice due to a compensatory T cell response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000237693:
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:48861968-48871683
Strand Reverse strand
Band B1.2
Transcripts
ENSMUST00000049519 ENSMUSP00000050446
ENSMUST00000097271 ENSMUSP00000094870
ENSMUST00000147151
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
GO:0016817 hydrolase activity, acting on acid anhydrides
Biological Process
GO:0006914 autophagy
GO:0006952 defense response
GO:0008152 metabolic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000139 Golgi membrane
GO:0000421 autophagic vacuole membrane
GO:0001891 phagocytic cup
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0031902 late endosome membrane
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000237693
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu05145
Toxoplasmosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05145
Toxoplasmosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5NCB5
UniProt Splice Variant
Entrez Gene 15944
UniGene Mm.29938
RefSeq NM_008326
OMIM
CCDS CCDS24588
HPRD
IMGT
MGI ID MGI:107567
MGI Symbol Irgm1
EMBL AL645849
GenPept
RNA Seq Atlas 15944

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca