InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cxcr1

Summary

InnateDB Protein

IDBP-166433.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcr1

Protein Name

chemokine (C-X-C motif) receptor 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049714

InnateDB Gene

IDBG-166431 (Cxcr1)

Protein Structure

UniProt Annotation

Function

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004918	interleukin-8 receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0019959	interleukin-8 binding

Biological Process

GO:0006935	chemotaxis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0031623	receptor internalization
GO:0038112	interleukin-8-mediated signaling pathway
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2448715

InterPro

IPR000174 CXC chemokine receptor 1/2
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR005384 Duffy antigen/chemokine receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00427
PR00237
PR00657
PR01559

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q810W6