InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxd3

Summary

InnateDB Protein

IDBP-166473.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxd3

Protein Name

forkhead box D3

Synonyms

CWH3; Genesis; Hfh2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084541

InnateDB Gene

IDBG-166471 (Foxd3)

Protein Structure

UniProt Annotation

Function

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. {ECO:0000269PubMed:12381664, ECO:0000269PubMed:8798505}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in premigratory and migrating neural crest cells in the early embryo and in motorneuron and interneuron progenitors in the developing spinal cord. {ECO:0000269PubMed:11684651, ECO:0000269PubMed:9767163}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001701	in utero embryonic development
GO:0001755	neural crest cell migration
GO:0001822	kidney development
GO:0001829	trophectodermal cell differentiation
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0007422	peripheral nervous system development
GO:0030318	melanocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048484	enteric nervous system development
GO:0048485	sympathetic nervous system development
GO:0048846	axon extension involved in axon guidance
GO:0048937	lateral line nerve glial cell development
GO:0050935	iridophore differentiation
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0051216	cartilage development