InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nkd2

Summary

InnateDB Protein

IDBP-166497.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nkd2

Protein Name

naked cuticle 2 homolog (Drosophila)

Synonyms

2210403L10Rik; AW212591;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022051

InnateDB Gene

IDBG-166495 (Nkd2)

Protein Structure

UniProt Annotation

Function

Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the cecum, colon, esophagus, ileum, jejunum, skin and stomach. {ECO:0000269PubMed:11356022, ECO:0000269PubMed:15064403, ECO:0000269PubMed:15546883}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019838	growth factor binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006887	exocytosis
GO:0010954	positive regulation of protein processing
GO:0016055	Wnt signaling pathway
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048210	Golgi vesicle fusion to target membrane
GO:0072661	protein targeting to plasma membrane
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0071944	cell periphery