Version 5.4
Mus musculus Gene: Nkd2
Summary
InnateDB Gene IDBG-166495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nkd2
Gene Name naked cuticle 2 homolog (Drosophila)
Synonyms 2210403L10Rik; AW212591
Species Mus musculus
Ensembl Gene ENSMUSG00000021567
Encoded Proteins
IDBP-166497
naked cuticle 2 homolog (Drosophila)
IDBP-400999
naked cuticle 2 homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145506:
This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:73818534-73847631
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000022051 ENSMUSP00000022051
ENSMUST00000118096 ENSMUSP00000113794
ENSMUST00000138899
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019838 growth factor binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006887 exocytosis
GO:0010954 positive regulation of protein processing
GO:0016055 Wnt signaling pathway
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048210 Golgi vesicle fusion to target membrane
GO:0072661 protein targeting to plasma membrane
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145506
View Gene Order
ENSBTAG00000034435
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04310
Wnt signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
wnt_canonical_pathway
Canonical Wnt signaling pathway
Cross-References
SwissProt Q8VE28
TrEMBL
UniProt Splice Variant
Entrez Gene 72293
UniGene Mm.427205 Mm.45506
RefSeq NM_028186 XM_006517396
OMIM
CCDS CCDS26636
HPRD
IMGT
MGI ID MGI:1919543
MGI Symbol Nkd2
EMBL AF358136 AK008814 AK081904 AK145155 AK146667 AK158350 BC019952
GenPept AAH19952 AAK57485 BAB25908 BAC38367 BAE26264 BAE27345 BAE34467
RNA Seq Atlas 72293

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca