InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp4f14

Summary

InnateDB Protein

IDBP-166519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp4f14

Protein Name

cytochrome P450, family 4, subfamily f, polypeptide 14

Synonyms

1300014O15Rik; cyp4f-14;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050478

InnateDB Gene

IDBG-166517 (Cyp4f14)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4 (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0050051	leukotriene-B4 20-monooxygenase activity
GO:0052871	alpha-tocopherol omega-hydroxylase activity

Biological Process

GO:0036101	leukotriene B4 catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

MGI:1927669

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00464
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9EP75