InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp4f14

Summary

InnateDB Gene

IDBG-166517.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp4f14

Gene Name

cytochrome P450, family 4, subfamily f, polypeptide 14

Synonyms

1300014O15Rik; cyp4f-14

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024292

Encoded Proteins

IDBP-166519

cytochrome P450, family 4, subfamily f, polypeptide 14

IDBP-715554

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186529:
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:32905071-32917342

Strand

Reverse strand

Band

Transcripts

ENSMUST00000054174	ENSMUSP00000050478
ENSMUST00000179434	ENSMUSP00000136139

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0050051	leukotriene-B4 20-monooxygenase activity
GO:0052871	alpha-tocopherol omega-hydroxylase activity