InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crb2

Summary

InnateDB Protein

IDBP-166562.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crb2

Protein Name

crumbs homolog 2 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058007

InnateDB Gene

IDBG-166560 (Crb2)

Protein Structure

UniProt Annotation

Function

May play a role in polarized cells morphogenesis.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

In the adult eye, strongly expressed in the outer nuclear layer, containing the cell bodies of the photoreceptor cells, and in the inner nuclear layer, containing the cell bodies of the horizontal, bipolar, amacrine, and Mueller glial cells. Also expressed in some cells in the ganglion cell layer (or may be displaced amacrine cells rather than ganglion cells). {ECO:0000269PubMed:15851977}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019828	aspartic-type endopeptidase inhibitor activity
GO:0019899	enzyme binding

Biological Process

GO:0001707	mesoderm formation
GO:0001756	somitogenesis
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010951	negative regulation of endopeptidase activity
GO:0014028	notochord formation
GO:0030513	positive regulation of BMP signaling pathway
GO:0045199	maintenance of epithelial cell apical/basal polarity
GO:0050896	response to stimulus
GO:0072358	cardiovascular system development

Cellular Component

GO:0016021	integral component of membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2679260

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00054
PF02210
PF07645

PRINTS

PIRSF

SMART

SM00181
SM00210
SM00282
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80YA8