InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctsg

Summary

InnateDB Protein

IDBP-166703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctsg

Protein Name

cathepsin G

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015583

InnateDB Gene

IDBG-166701 (Ctsg)

Protein Structure

UniProt Annotation

Function

This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis.

Subcellular Localization

Membrane. Note=Strongly associated with membranes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008201	heparin binding
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0032496	response to lipopolysaccharide
GO:0044130	negative regulation of growth of symbiont in host
GO:0050778	positive regulation of immune response
GO:0050830	defense response to Gram-positive bacterium
GO:0050832	defense response to fungus
GO:0070946	neutrophil mediated killing of gram-positive bacterium

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0030141	secretory granule
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome