InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ctsg

Summary

InnateDB Gene

IDBG-166701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctsg

Gene Name

cathepsin G

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040314

Encoded Proteins

IDBP-166703

cathepsin G

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18762176

[Homo sapiens] CTSG, a cathepsin, is a key modulator of cell death and inflammatory responses.

PMID 20676107

[Homo sapiens] ELANE and CTSG, together with externalized nucleosomes, promote coagulation and intravascular thrombus growth in vivo. During systemic infection, activation of coagulation fosters compartmentalization of bacteria in liver microvessels and reduces bacterial invasion into tissue.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100448:
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:56099881-56102574

Strand

Reverse strand

Band

Transcripts

ENSMUST00000015583

ENSMUSP00000015583

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008201	heparin binding
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0032496	response to lipopolysaccharide
GO:0044130	negative regulation of growth of symbiont in host
GO:0050778	positive regulation of immune response
GO:0050830	defense response to Gram-positive bacterium
GO:0050832	defense response to fungus
GO:0070946	neutrophil mediated killing of gram-positive bacterium

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0030141	secretory granule
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome