InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp7a

Summary

InnateDB Protein

IDBP-166775.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Atp7a

Protein Name

ATPase, Cu++ transporting, alpha polypeptide

Synonyms

MNK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058840

InnateDB Gene

IDBG-166773 (Atp7a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004008	copper-exporting ATPase activity
GO:0005375	copper ion transmembrane transporter activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016532	superoxide dismutase copper chaperone activity
GO:0019829	cation-transporting ATPase activity
GO:0032767	copper-dependent protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001568	blood vessel development
GO:0001701	in utero embryonic development
GO:0001836	release of cytochrome c from mitochondria
GO:0001974	blood vessel remodeling
GO:0002082	regulation of oxidative phosphorylation
GO:0006568	tryptophan metabolic process
GO:0006570	tyrosine metabolic process
GO:0006584	catecholamine metabolic process
GO:0006812	cation transport
GO:0006825	copper ion transport
GO:0006878	cellular copper ion homeostasis
GO:0007005	mitochondrion organization
GO:0007595	lactation
GO:0007626	locomotory behavior
GO:0010041	response to iron(III) ion
GO:0010043	response to zinc ion
GO:0010273	detoxification of copper ion
GO:0010468	regulation of gene expression
GO:0015677	copper ion import
GO:0015679	plasma membrane copper ion transport
GO:0018205	peptidyl-lysine modification
GO:0019430	removal of superoxide radicals
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021860	pyramidal neuron development
GO:0021954	central nervous system neuron development
GO:0030001	metal ion transport
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0031069	hair follicle morphogenesis
GO:0042093	T-helper cell differentiation
GO:0042414	epinephrine metabolic process
GO:0042415	norepinephrine metabolic process
GO:0042417	dopamine metabolic process
GO:0042421	norepinephrine biosynthetic process
GO:0042428	serotonin metabolic process
GO:0043085	positive regulation of catalytic activity
GO:0043473	pigmentation
GO:0043524	negative regulation of neuron apoptotic process
GO:0043588	skin development
GO:0046034	ATP metabolic process
GO:0046688	response to copper ion
GO:0048251	elastic fiber assembly
GO:0048286	lung alveolus development
GO:0048553	negative regulation of metalloenzyme activity
GO:0048554	positive regulation of metalloenzyme activity
GO:0048812	neuron projection morphogenesis
GO:0048813	dendrite morphogenesis
GO:0051216	cartilage development
GO:0051353	positive regulation of oxidoreductase activity
GO:0051542	elastin biosynthetic process
GO:0060003	copper ion export

Cellular Component

GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030140	trans-Golgi network transport vesicle
GO:0030141	secretory granule
GO:0031410	cytoplasmic vesicle
GO:0031526	brush border membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:99400

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR001802 Mercury scavenger protein
IPR006121 Heavy metal-associated domain, HMA
IPR006122 Heavy metal-associated domain, copper ion-binding
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR027256 Cation-transporting P-type ATPase, subfamily IB

PFAM

PF00403
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120
PR00946
PR00941

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite