InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gata2

Summary

InnateDB Protein

IDBP-166780.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gata2

Protein Name

GATA binding protein 2

Synonyms

Gata-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015197

InnateDB Gene

IDBG-166776 (Gata2)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	2 [view]
Protein-DNA	19 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001655	urogenital system development
GO:0001709	cell fate determination
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006909	phagocytosis
GO:0021514	ventral spinal cord interneuron differentiation
GO:0021533	cell differentiation in hindbrain
GO:0021902	commitment of neuronal cell to specific neuron type in forebrain
GO:0021954	central nervous system neuron development
GO:0021983	pituitary gland development
GO:0030154	cell differentiation
GO:0030182	neuron differentiation
GO:0035019	somatic stem cell maintenance
GO:0035065	regulation of histone acetylation
GO:0035854	eosinophil fate commitment
GO:0042472	inner ear morphogenesis
GO:0045599	negative regulation of fat cell differentiation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045650	negative regulation of macrophage differentiation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0048663	neuron fate commitment
GO:0048873	homeostasis of number of cells within a tissue
GO:0050766	positive regulation of phagocytosis
GO:0060216	definitive hemopoiesis
GO:0060872	semicircular canal development
GO:0070345	negative regulation of fat cell proliferation
GO:0097154	GABAergic neuron differentiation
GO:2000178	negative regulation of neural precursor cell proliferation
GO:2000977	regulation of forebrain neuron differentiation