InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gata2

Summary

InnateDB Gene

IDBG-166776.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gata2

Gene Name

GATA binding protein 2

Synonyms

Gata-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015053

Encoded Proteins

IDBP-166780

GATA binding protein 2

IDBP-620557

GATA binding protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179348:
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:88193891-88207030

Strand

Forward strand

Band

Transcripts

ENSMUST00000015197	ENSMUSP00000015197
ENSMUST00000170089	ENSMUSP00000128198

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	2 [view]
Protein-DNA	19 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001655	urogenital system development
GO:0001709	cell fate determination
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006909	phagocytosis
GO:0021514	ventral spinal cord interneuron differentiation
GO:0021533	cell differentiation in hindbrain
GO:0021902	commitment of neuronal cell to specific neuron type in forebrain
GO:0021954	central nervous system neuron development
GO:0021983	pituitary gland development
GO:0030154	cell differentiation
GO:0030182	neuron differentiation
GO:0035019	somatic stem cell maintenance
GO:0035065	regulation of histone acetylation
GO:0035854	eosinophil fate commitment
GO:0042472	inner ear morphogenesis
GO:0045599	negative regulation of fat cell differentiation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045650	negative regulation of macrophage differentiation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0048663	neuron fate commitment
GO:0048873	homeostasis of number of cells within a tissue
GO:0050766	positive regulation of phagocytosis
GO:0060216	definitive hemopoiesis
GO:0060872	semicircular canal development
GO:0070345	negative regulation of fat cell proliferation
GO:0097154	GABAergic neuron differentiation
GO:2000178	negative regulation of neural precursor cell proliferation
GO:2000977	regulation of forebrain neuron differentiation