InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pofut2

Summary

InnateDB Protein

IDBP-166808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pofut2

Protein Name

protein O-fucosyltransferase 2

Synonyms

2310011G23Rik; AI256847; BC003494; C21orf80; FUT13;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020493

InnateDB Gene

IDBG-166806 (Pofut2)

Protein Structure

UniProt Annotation

Function

Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombosporin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13 (By similarity). O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm. {ECO:0000250, ECO:0000269PubMed:20637190}.

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Mainly located in the endoplasmic reticulum. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008417	fucosyltransferase activity
GO:0046922	peptide-O-fucosyltransferase activity

Biological Process

GO:0001707	mesoderm formation
GO:0006004	fucose metabolic process
GO:0010468	regulation of gene expression
GO:0010717	regulation of epithelial to mesenchymal transition
GO:0036065	fucosylation
GO:0036066	protein O-linked fucosylation
GO:0051046	regulation of secretion