Mus musculus Protein: Gzmc
Summary
InnateDB Protein IDBP-166918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gzmc
Protein Name granzyme C
Synonyms AI323531; CCP2; Ctla-5; Ctla5;
Species Mus musculus
Ensembl Protein ENSMUSP00000015585
InnateDB Gene IDBG-258415 (Gzmc)
Protein Structure
UniProt Annotation
Function This enzyme is probably necessary for target cell lysis in cell-mediated immune responses.
Subcellular Localization Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0019835 cytolysis
Cellular Component
GO:0030141 secretory granule
Protein Structure and Domains
PDB ID MGI:109256
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P08882
PhosphoSite PhosphoSite-
TrEMBL Q0VB76
UniProt Splice Variant
Entrez Gene 14940
UniGene Mm.14465
RefSeq NP_034501
MGI ID 3G01
MGI Symbol Gzmc
OMIM
CCDS CCDS27146
HPRD
IMGT
EMBL BC120755 BC120757 BC145030 CH466535 M12301 M18459 M22527 X12822
GenPept AAA37384 AAA37734 AAA85454 AAI20756 AAI20758 AAI45031 CAA31309 EDL36203