InnateDB Protein
|
IDBP-167020.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Ints3
|
Protein Name
|
integrator complex subunit 3
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000029542
|
InnateDB Gene
|
IDBG-167018 (Ints3)
|
Protein Structure
|
|
Function |
Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). {ECO:0000250}.Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single- stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus {ECO:0000250}. Note=Localizes to nuclear foci following DNA damage. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
|
Protein-Protein |
10
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
39 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2140050
|
InterPro |
IPR019333
Integrator complex subunit 3
|
PFAM |
PF10189
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q7TPD0
|
PhosphoSite |
PhosphoSite-Q7TPD0
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
229543
|
UniGene |
Mm.268564
|
RefSeq |
NP_663515
|
MGI ID |
|
MGI Symbol |
Ints3
|
OMIM |
|
CCDS |
CCDS17528
|
HPRD |
|
IMGT |
|
EMBL |
AK040147
AK043206
BC003209
BC055344
|
GenPept |
AAH03209
AAH55344
BAC30523
BAC31492
|
|
|