Version 5.4
Mus musculus Gene: Ints3
Summary
InnateDB Gene IDBG-167018.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ints3
Gene Name integrator complex subunit 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027933
Encoded Proteins
IDBP-167020
integrator complex subunit 3
IDBP-167022
integrator complex subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143624:
INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). INTS3 is also a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:90391380-90433636
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000029542 ENSMUSP00000029542
ENSMUST00000071488 ENSMUSP00000071422
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007093 mitotic cell cycle checkpoint
GO:0010212 response to ionizing radiation
GO:0016180 snRNA processing
Cellular Component
GO:0005634 nucleus
GO:0032039 integrator complex
GO:0070876 SOSS complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143624
View Gene Order
ENSBTAG00000006235
Not yet available
Cross-References
SwissProt Q7TPD0
TrEMBL
UniProt Splice Variant
Entrez Gene 229543
UniGene Mm.268564
RefSeq NM_145540 NM_178876
OMIM
CCDS CCDS17528
HPRD
IMGT
MGI ID MGI:2140050
MGI Symbol Ints3
EMBL AK040147 AK043206 BC003209 BC055344
GenPept AAH03209 AAH55344 BAC30523 BAC31492
RNA Seq Atlas 229543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca