InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp12a

Summary

InnateDB Protein

IDBP-167044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp12a

Protein Name

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007340

InnateDB Gene

IDBG-167042 (Atp12a)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Found in skin, kidney and distal colon. {ECO:0000269PubMed:9872395}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008900	hydrogen:potassium-exchanging ATPase activity
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006885	regulation of pH
GO:0015672	monovalent inorganic cation transport
GO:0055075	potassium ion homeostasis
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Protein Structure and Domains

PDB ID

MGI:1926943

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt