InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sec61a1

Summary

InnateDB Protein

IDBP-167086.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sec61a1

Protein Name

Sec61 alpha 1 subunit (S. cerevisiae)

Synonyms

AA408394; AA410007; Sec61a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032168

InnateDB Gene

IDBG-167084 (Sec61a1)

Protein Structure

UniProt Annotation

Function

Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adaptor proteins.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043022	ribosome binding

Biological Process

GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006620	posttranslational protein targeting to membrane
GO:0007029	endoplasmic reticulum organization
GO:0015031	protein transport
GO:0016049	cell growth
GO:0034341	response to interferon-gamma

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005791	rough endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane