Version 5.4
Mus musculus Gene: Sec61a1
Summary
InnateDB Gene IDBG-167084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sec61a1
Gene Name Sec61 alpha 1 subunit (S. cerevisiae)
Synonyms AA408394; AA410007; Sec61a
Species Mus musculus
Ensembl Gene ENSMUSG00000030082
Encoded Proteins
IDBP-167086
Sec61 alpha 1 subunit (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000058262:
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:88503601-88518905
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000032168 ENSMUSP00000032168
ENSMUST00000136103
ENSMUST00000145421
ENSMUST00000130918
ENSMUST00000130807
ENSMUST00000139676
ENSMUST00000139551
ENSMUST00000125016
ENSMUST00000155079
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043022 ribosome binding
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006620 posttranslational protein targeting to membrane
GO:0007029 endoplasmic reticulum organization
GO:0015031 protein transport
GO:0016049 cell growth
GO:0034341 response to interferon-gamma
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005791 rough endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030670 phagocytic vesicle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000058262
View Gene Order
ENSBTAG00000004937
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_254308
Translation pathway
REACT_230745
Immune System pathway
REACT_247926
Metabolism of proteins pathway
REACT_199105
ER-Phagosome pathway pathway
REACT_196445
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_199113
Antigen processing-Cross presentation pathway
REACT_233572
Gene Expression pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu03060
Protein export pathway
mmu04145
Phagosome pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111178
ER-Phagosome pathway pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_1014
Translation pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_71
Gene Expression pathway
REACT_211738
ER-Phagosome pathway pathway
REACT_221721
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_212672
Class I MHC mediated antigen processing & presentation pathway
REACT_226022
Gene Expression pathway
REACT_213138
Immune System pathway
REACT_209048
Translation pathway
REACT_213782
Metabolism of proteins pathway
REACT_214469
Adaptive Immune System pathway
REACT_218645
Antigen processing-Cross presentation pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa03060
Protein export pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28375 Mm.449144 Mm.489945
RefSeq NM_016906
OMIM
CCDS CCDS39553
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca