InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pi4k2a

Summary

InnateDB Protein

IDBP-167163.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pi4k2a

Protein Name

phosphatidylinositol 4-kinase type 2 alpha

Synonyms

Pi4k2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069284

InnateDB Gene

IDBG-167161 (Pi4k2a)

Protein Structure

UniProt Annotation

Function

Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells. This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Membrane raft {ECO:0000250}. Endosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell projection, dendrite {ECO:0000269PubMed:21998198}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269PubMed:21998198}. Cell junction, synapse, synaptosome {ECO:0000269PubMed:21998198}. Mitochondrion {ECO:0000269PubMed:21998198}. Note=Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. Enriched in neurite tips and neuron projections in a BLOC- 1- and AP-3-complexes-dependent manner (By similarity). Localized in neuronal cell body. Transported from neuronal cell body to neuron projections in a BLOC-1- and AP-3-complexes-dependent manner. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004430	1-phosphatidylinositol 4-kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0032403	protein complex binding
GO:0035651	AP-3 adaptor complex binding

Biological Process

GO:0002561	basophil degranulation
GO:0006661	phosphatidylinositol biosynthetic process
GO:0046854	phosphatidylinositol phosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0030672	synaptic vesicle membrane
GO:0031083	BLOC-1 complex
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane
GO:0035838	growing cell tip
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0044231	host cell presynaptic membrane
GO:0045121	membrane raft
GO:0070382	exocytic vesicle