InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pi4k2a

Summary

InnateDB Gene

IDBG-167161.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pi4k2a

Gene Name

phosphatidylinositol 4-kinase type 2 alpha

Synonyms

Pi4k2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025178

Encoded Proteins

IDBP-167163

phosphatidylinositol 4-kinase type 2 alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155252:
Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:42090435-42122218

Strand

Forward strand

Band

Transcripts

ENSMUST00000066778

ENSMUSP00000069284

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004430	1-phosphatidylinositol 4-kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0032403	protein complex binding
GO:0035651	AP-3 adaptor complex binding

Biological Process

GO:0002561	basophil degranulation
GO:0006661	phosphatidylinositol biosynthetic process
GO:0046854	phosphatidylinositol phosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0030672	synaptic vesicle membrane
GO:0031083	BLOC-1 complex
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane
GO:0035838	growing cell tip
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0044231	host cell presynaptic membrane
GO:0045121	membrane raft
GO:0070382	exocytic vesicle