InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp4f18

Summary

InnateDB Protein

IDBP-167300.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp4f18

Protein Name

cytochrome P450, family 4, subfamily f, polypeptide 18

Synonyms

1810054N16Rik; Cyp4f3; Cypf18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003574

InnateDB Gene

IDBG-167298 (Cyp4f18)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes. {ECO:0000250UniProtKB:Q08477, ECO:0000269PubMed:16380383}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest level in polymorphonuclear leukocytes and dendritic cells. Detectable in lymph nodes, spleen, bone marrow and peripheral blood. Highly expressed in ovary. Very low level in liver, kidney, and smooth muscle. {ECO:0000269PubMed:16380383}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0050051	leukotriene-B4 20-monooxygenase activity
GO:0052871	alpha-tocopherol omega-hydroxylase activity

Biological Process

GO:0036101	leukotriene B4 catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1919304

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00464
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99N16