InnateDB Protein
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IDBP-16733.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PIF1
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Protein Name
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PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000328174
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InnateDB Gene
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IDBG-16729 (PIF1)
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Protein Structure
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Function |
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255HAMAP-Rule:MF_03176, ECO:0000269PubMed:16522649, ECO:0000269PubMed:17172855, ECO:0000269PubMed:17827721, ECO:0000269PubMed:18835853, ECO:0000269PubMed:19700773, ECO:0000269PubMed:20524933, ECO:0000269PubMed:23657261}.
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Subcellular Localization |
Nucleus {ECO:0000255HAMAP-Rule:MF_03176, ECO:0000269PubMed:16522649, ECO:0000269PubMed:17172855, ECO:0000269PubMed:17827721}.Isoform 4: Mitochondrion {ECO:0000255HAMAP- Rule:MF_03176, ECO:0000269PubMed:23275553}.
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Disease Associations |
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Tissue Specificity |
Weak ubiquitous expression.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003840
DNA helicase
IPR010285
DNA helicase Pif1 like
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF02689
PF05970
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H611
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PhosphoSite |
PhosphoSite-Q9H611
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80119
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UniGene |
Hs.112160
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RefSeq |
NP_001273426
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HUGO |
HGNC:26220
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OMIM |
610953
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CCDS |
CCDS66797
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HPRD |
10715
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IMGT |
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EMBL |
AB185926
AB185927
AK026345
AY498716
BC137503
BC137504
DQ437529
EU084033
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GenPept |
AAI37504
AAI37505
AAS77398
ABD92708
ABW71293
BAB15456
BAE47454
BAE47455
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