InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rqcd1

Summary

InnateDB Protein

IDBP-167356.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rqcd1

Protein Name

rcd1 (required for cell differentiation) homolog 1 (S. pombe)

Synonyms

2610007F23Rik; AI593551; Fl10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084466

InnateDB Gene

IDBG-167354 (Rqcd1)

Protein Structure

UniProt Annotation

Function

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Required for retinoic acid-induced differentiation of F9 teratocarcinoma cells. Does not bind DNA by itself. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation. {ECO:0000269PubMed:12356739, ECO:0000269PubMed:15209511}.

Subcellular Localization

Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body.

Disease Associations

Tissue Specificity

Detected at low levels in bone marrow and thymus. {ECO:0000269PubMed:10880228}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006417	regulation of translation
GO:0019221	cytokine-mediated signaling pathway
GO:0031047	gene silencing by RNA
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity