InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sumo3

Summary

InnateDB Protein

IDBP-167404.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sumo3

Protein Name

SMT3 suppressor of mif two 3 homolog 3 (yeast)

Synonyms

2810014B19Rik; D10Ertd345e; SMT3A; Smt3h1; SUMO-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020501

InnateDB Gene

IDBG-167402 (Sumo3)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000269PubMed:18644859}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019789	SUMO ligase activity

Biological Process

GO:0016925	protein sumoylation
GO:0034504	protein localization to nucleus
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process