InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AES

Summary

InnateDB Protein

IDBP-16757.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AES

Protein Name

amino-terminal enhancer of split

Synonyms

AES-1; AES-2; ESP1; GRG; GRG5; TLE5;

Species

Homo sapiens

Ensembl Protein

ENSP00000317537

InnateDB Gene

IDBG-16753 (AES)

Protein Structure

UniProt Annotation

Function

Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. {ECO:0000269PubMed:10660609, ECO:0000269PubMed:10748198}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 145 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	145 [view]
Protein-Protein	145 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0009887	organ morphogenesis
GO:0010629	negative regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0032091	negative regulation of protein binding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060761	negative regulation of response to cytokine stimulus
GO:0070555	response to interleukin-1
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000210	positive regulation of anoikis