InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AES

Summary

InnateDB Gene

IDBG-16753.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AES

Gene Name

amino-terminal enhancer of split

Synonyms

AES-1; AES-2; ESP1; GRG; GRG5; TLE5

Species

Homo sapiens

Ensembl Gene

ENSG00000104964

Encoded Proteins

IDBP-16755

amino-terminal enhancer of split

IDBP-16757

amino-terminal enhancer of split

IDBP-761422

IDBP-765288

IDBP-765789

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:3052910-3063107

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000221561	ENSP00000221561
ENST00000327141	ENSP00000317537
ENST00000586742	ENSP00000466038
ENST00000590067
ENST00000592330
ENST00000585557	ENSP00000466179
ENST00000585782
ENST00000587083
ENST00000592414
ENST00000587393
ENST00000586839	ENSP00000467831
ENST00000586003

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 145 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	145 [view]
Protein-Protein	145 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0009887	organ morphogenesis
GO:0010629	negative regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0031668	cellular response to extracellular stimulus
GO:0032091	negative regulation of protein binding
GO:0040008	regulation of growth
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060761	negative regulation of response to cytokine stimulus
GO:0070555	response to interleukin-1
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000210	positive regulation of anoikis