InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Uchl1

Summary

InnateDB Protein

IDBP-167603.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uchl1

Protein Name

ubiquitin carboxy-terminal hydrolase L1

Synonyms

AW822034; C88048; gad; PGP 9.5; PGP9.5; R75593; UCH-L1; UCHL-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031131

InnateDB Gene

IDBG-167601 (Uchl1)

Protein Structure

UniProt Annotation

Function

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. {ECO:0000269PubMed:12913066}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12913066}. Endoplasmic reticulum membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, where it is found in neurons but not in oligodendrocytes or astrocytes. Found in the ganglion cell layer and the inner nuclear layer of the retina (at protein level). Expressed in brain and testis. In the brain, expression is at its lowest in replaceable neurons of hippocampus and olfactory bulb. Highly expressed in senescent pituitary. {ECO:0000269PubMed:10471497, ECO:0000269PubMed:12559414, ECO:0000269PubMed:12913066, ECO:0000269PubMed:14695319, ECO:0000269PubMed:15911766}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008242	omega peptidase activity
GO:0016874	ligase activity
GO:0031694	alpha-2A adrenergic receptor binding
GO:0043130	ubiquitin binding

Biological Process

GO:0002931	response to ischemia
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007409	axonogenesis
GO:0007412	axon target recognition
GO:0007628	adult walking behavior
GO:0008283	cell proliferation
GO:0016579	protein deubiquitination
GO:0019233	sensory perception of pain
GO:0019896	axon transport of mitochondrion
GO:0042755	eating behavior
GO:0043407	negative regulation of MAP kinase activity
GO:0048747	muscle fiber development
GO:0050905	neuromuscular process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome