InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lepr

Summary

InnateDB Protein

IDBP-167736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lepr

Protein Name

leptin receptor

Synonyms

db; diabetes; Leprb; LEPROT; Modb1; OB-RGRP; obese-like; obl; Obr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099838

InnateDB Gene

IDBG-167734 (Lepr)

Protein Structure

UniProt Annotation

Function

Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway.Isoform A may act to transport leptin to the cerebrospinal fluid. {ECO:0000250}.Isoform E could function as a transport protein.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.Isoform E: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform A: highest level of expression in lung and kidney, also present in kidney, heart, brain, spleen, liver, muscle, choroid plexus and hypothalamus. Isoform B: highest level of expression in hypothalamus and lower level in brain, testes and adipose tissue. Isoform E: expressed in adipose tissue, hypothalamus, heart, and testes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004896	cytokine receptor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0007165	signal transduction
GO:0008203	cholesterol metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0019222	regulation of metabolic process
GO:0045721	negative regulation of gluconeogenesis
GO:0051346	negative regulation of hydrolase activity