InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lepr

Summary

InnateDB Gene

IDBG-167734.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lepr

Gene Name

leptin receptor

Synonyms

db; diabetes; Leprb; LEPROT; Modb1; OB-RGRP; obese-like; obl; Obr

Species

Mus musculus

Ensembl Gene

ENSMUSG00000057722

Encoded Proteins

IDBP-167736

leptin receptor

IDBP-167740

leptin receptor

IDBP-267751

leptin receptor

IDBP-536271

leptin receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116678:
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:101717404-101815352

Strand

Forward strand

Band

Transcripts

ENSMUST00000102777	ENSMUSP00000099838
ENSMUST00000037552	ENSMUSP00000037385
ENSMUST00000106921	ENSMUSP00000102534
ENSMUST00000145024	ENSMUSP00000123654
ENSMUST00000128948
ENSMUST00000156402
ENSMUST00000151733

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004896	cytokine receptor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0007165	signal transduction
GO:0008203	cholesterol metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0019222	regulation of metabolic process
GO:0045721	negative regulation of gluconeogenesis
GO:0051346	negative regulation of hydrolase activity

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0043235	receptor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000116678

View Gene Order

ENSBTAG00000005910

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04060

Cytokine-cytokine receptor interaction pathway

mmu04630

Jak-STAT signaling pathway pathway

mmu04080

Neuroactive ligand-receptor interaction pathway

mmu04920

Adipocytokine signaling pathway pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_22

Leptin pathway

REACTOME

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

hsa04920

Adipocytokine signaling pathway pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

PID NCI

ptp1bpathway

Signaling events mediated by PTP1B

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.259282 Mm.407284

RefSeq

NM_001122899 NM_010704 NM_146146

OMIM

CCDS

CCDS18397 CCDS51239 CCDS51240

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas