InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcs1l

Summary

InnateDB Protein

IDBP-167752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcs1l

Protein Name

BCS1-like (yeast)

Synonyms

9130022O19Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027358

InnateDB Gene

IDBG-167750 (Bcs1l)

Protein Structure

UniProt Annotation

Function

Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0007005	mitochondrion organization
GO:0008152	metabolic process
GO:0032981	mitochondrial respiratory chain complex I assembly
GO:0033617	mitochondrial respiratory chain complex IV assembly
GO:0034551	mitochondrial respiratory chain complex III assembly

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1914071

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR014851 BCS1, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF08740

PRINTS

PIRSF

SMART

SM00382
SM01024

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CZP5