Version 5.4
Mus musculus Gene: Bcs1l
Summary
InnateDB Gene IDBG-167750.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcs1l
Gene Name BCS1-like (yeast)
Synonyms 9130022O19Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000026172
Encoded Proteins
IDBP-167752
BCS1-like (yeast)
IDBP-253264
BCS1-like (yeast)
IDBP-253266
BCS1-like (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074582:
This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Five alternatively spliced transcripts encoding the same protein have been described. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74588289-74592443
Strand Forward strand
Band C3
Transcripts
ENSMUST00000027358 ENSMUSP00000027358
ENSMUST00000113733 ENSMUSP00000109362
ENSMUST00000113732 ENSMUSP00000109361
ENSMUST00000147464
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0007005 mitochondrion organization
GO:0008152 metabolic process
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0033617 mitochondrial respiratory chain complex IV assembly
GO:0034551 mitochondrial respiratory chain complex III assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000074582
View Gene Order
ENSBTAG00000003813
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.358700
RefSeq NM_025784 XM_006496196
OMIM
CCDS CCDS15051
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca