InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Angptl4

Summary

InnateDB Protein

IDBP-167869.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Angptl4

Protein Name

angiopoietin-like 4

Synonyms

Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg; Pp1158;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002360

InnateDB Gene

IDBG-167867 (Angptl4)

Protein Structure

UniProt Annotation

Function

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. {ECO:0000250, ECO:0000269PubMed:15837923, ECO:0000269PubMed:17068295, ECO:0000269PubMed:17130448}.

Subcellular Localization

Secreted {ECO:0000269PubMed:17068295}. Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:17068295}. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.

Disease Associations

Note=Elevated levels of expression in models of obesity and diabetes.

Tissue Specificity

Predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. {ECO:0000269PubMed:10862772}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0009267	cellular response to starvation
GO:0043066	negative regulation of apoptotic process
GO:0045834	positive regulation of lipid metabolic process
GO:0051005	negative regulation of lipoprotein lipase activity
GO:0051260	protein homooligomerization
GO:0070328	triglyceride homeostasis
GO:2000352	negative regulation of endothelial cell apoptotic process