InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Angptl4

Summary

InnateDB Gene

IDBG-167867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Angptl4

Gene Name

angiopoietin-like 4

Synonyms

Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg; Pp1158

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002289

Encoded Proteins

IDBP-167869

angiopoietin-like 4

IDBP-626588

angiopoietin-like 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167772:
This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:33773750-33781575

Strand

Reverse strand

Band

Transcripts

ENSMUST00000002360	ENSMUSP00000002360
ENSMUST00000173869	ENSMUSP00000133417
ENSMUST00000174858
ENSMUST00000174872

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0009267	cellular response to starvation
GO:0043066	negative regulation of apoptotic process
GO:0045834	positive regulation of lipid metabolic process
GO:0051005	negative regulation of lipoprotein lipase activity
GO:0051260	protein homooligomerization
GO:0070328	triglyceride homeostasis
GO:2000352	negative regulation of endothelial cell apoptotic process