InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stk36

Summary

InnateDB Protein

IDBP-167906.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stk36

Protein Name

serine/threonine kinase 36 (fused homolog, Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084433

InnateDB Gene

IDBG-167898 (Stk36)

Protein Structure

UniProt Annotation

Function

Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. {ECO:0000269PubMed:16055717, ECO:0000269PubMed:18600476, ECO:0000269PubMed:19305393}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19305393}. Nucleus {ECO:0000250}. Note=Low levels also present in the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Weakly expressed in the heart and thymus, present at moderate to high levels in the lungs, pancreas, and kidneys and at higher levels in the brain and cerebellum. Very highly expressed in the testis. {ECO:0000269PubMed:16055717, ECO:0000269PubMed:18600476}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0003351	epithelial cilium movement
GO:0006468	protein phosphorylation
GO:0007228	positive regulation of hh target transcription factor activity
GO:0007420	brain development
GO:0009791	post-embryonic development
GO:0042384	cilium assembly
GO:0045880	positive regulation of smoothened signaling pathway
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1920831

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt