Version 5.4
Mus musculus Gene: Stk36
Summary
InnateDB Gene IDBG-167898.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stk36
Gene Name serine/threonine kinase 36
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000033276
Encoded Proteins
IDBP-167902
serine/threonine kinase 36 (fused homolog, Drosophila)
IDBP-167906
serine/threonine kinase 36 (fused homolog, Drosophila)
IDBP-253298
serine/threonine kinase 36 (fused homolog, Drosophila)
IDBP-538470
serine/threonine kinase 36 (fused homolog, Drosophila)
IDBP-787782
serine/threonine kinase 36
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163482:
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74601445-74636894
Strand Forward strand
Band C3
Transcripts
ENSMUST00000087183 ENSMUSP00000084430
ENSMUST00000087186 ENSMUSP00000084433
ENSMUST00000113694 ENSMUSP00000109324
ENSMUST00000145673
ENSMUST00000148456 ENSMUSP00000120020
ENSMUST00000157007
ENSMUST00000155473
ENSMUST00000123154
ENSMUST00000189830 ENSMUSP00000140912
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0003351 epithelial cilium movement
GO:0006468 protein phosphorylation
GO:0007228 positive regulation of hh target transcription factor activity
GO:0007420 brain development
GO:0009791 post-embryonic development
GO:0042384 cilium assembly
GO:0045880 positive regulation of smoothened signaling pathway
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163482
View Gene Order
ENSBTAG00000003819
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05217
Basal cell carcinoma pathway
mmu04340
Hedgehog signaling pathway pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
KEGG
hsa04340
Hedgehog signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.310974
RefSeq NM_175031 XM_006496039
OMIM
CCDS CCDS35619
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca