InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stxbp1

Summary

InnateDB Protein

IDBP-168082.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stxbp1

Protein Name

syntaxin binding protein 1

Synonyms

AI317162; AI326233; MMS10-G; Ms10g; Munc-18a; Munc18-1; N-sec1; nsec1; Rb-sec1; Sxtbp1; Unc18-1; Unc18h;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089051

InnateDB Gene

IDBG-161623 (Stxbp1)

Protein Structure

UniProt Annotation

Function

May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding
GO:0017075	syntaxin-1 binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0019905	syntaxin binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0002576	platelet degranulation
GO:0006887	exocytosis
GO:0006904	vesicle docking involved in exocytosis
GO:0007269	neurotransmitter secretion
GO:0007274	neuromuscular synaptic transmission
GO:0007412	axon target recognition
GO:0010807	regulation of synaptic vesicle priming
GO:0015031	protein transport
GO:0016188	synaptic vesicle maturation
GO:0016192	vesicle-mediated transport
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0043524	negative regulation of neuron apoptotic process
GO:0045921	positive regulation of exocytosis
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0050821	protein stabilization
GO:0060292	long term synaptic depression
GO:0070527	platelet aggregation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0031091	platelet alpha granule
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome