InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stxbp1

Summary

InnateDB Gene

IDBG-161623.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stxbp1

Gene Name

syntaxin binding protein 1

Synonyms

AI317162; AI326233; MMS10-G; Ms10g; Munc-18a; Munc18-1; N-sec1; nsec1; Rb-sec1; Sxtbp1; Unc18-1; Unc18h

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026797

Encoded Proteins

IDBP-161625

syntaxin binding protein 1

IDBP-168082

syntaxin binding protein 1

IDBP-254339

syntaxin binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136854:
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:32787602-32847239

Strand

Reverse strand

Band

Transcripts

ENSMUST00000050000	ENSMUSP00000052440
ENSMUST00000077458	ENSMUSP00000089051
ENSMUST00000113222	ENSMUSP00000108848

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding
GO:0017075	syntaxin-1 binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0019905	syntaxin binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0002576	platelet degranulation
GO:0006887	exocytosis
GO:0006904	vesicle docking involved in exocytosis
GO:0007269	neurotransmitter secretion
GO:0007274	neuromuscular synaptic transmission
GO:0007412	axon target recognition
GO:0010807	regulation of synaptic vesicle priming
GO:0015031	protein transport
GO:0016188	synaptic vesicle maturation
GO:0016192	vesicle-mediated transport
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0043524	negative regulation of neuron apoptotic process
GO:0045921	positive regulation of exocytosis
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0050821	protein stabilization
GO:0060292	long term synaptic depression
GO:0070527	platelet aggregation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0031091	platelet alpha granule
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome