InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sgip1

Summary

InnateDB Protein

IDBP-168110.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sgip1

Protein Name

SH3-domain GRB2-like (endophilin) interacting protein 1

Synonyms

3110007P09Rik; gag; SGIP1alpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063712

InnateDB Gene

IDBG-168106 (Sgip1)

Protein Structure

UniProt Annotation

Function

May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000269PubMed:17626015, ECO:0000269PubMed:21747946}.

Subcellular Localization

Membrane, clathrin-coated pit {ECO:0000305PubMed:17626015}; Peripheral membrane protein {ECO:0000305PubMed:17626015}; Cytoplasmic side {ECO:0000305PubMed:17626015}.

Disease Associations

Tissue Specificity

Detected in brain, spinal cord and cerebellum. {ECO:0000269PubMed:21747946}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0017124	SH3 domain binding

Biological Process

GO:0002021	response to dietary excess
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0016192	vesicle-mediated transport
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0097320	membrane tubulation
GO:2000253	positive regulation of feeding behavior
GO:2000507	positive regulation of energy homeostasis