InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sgip1

Summary

InnateDB Gene

IDBG-168106.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sgip1

Gene Name

SH3-domain GRB2-like (endophilin) interacting protein 1

Synonyms

3110007P09Rik; gag; SGIP1alpha

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028524

Encoded Proteins

IDBP-168108

SH3-domain GRB2-like (endophilin) interacting protein 1

IDBP-168110

SH3-domain GRB2-like (endophilin) interacting protein 1

IDBP-168112

SH3-domain GRB2-like (endophilin) interacting protein 1

IDBP-168114

SH3-domain GRB2-like (endophilin) interacting protein 1

IDBP-267810

SH3-domain GRB2-like (endophilin) interacting protein 1

IDBP-534738

SH3-domain GRB2-like (endophilin) interacting protein 1

IDBP-536342

SH3-domain GRB2-like (endophilin) interacting protein 1

IDBP-787817

SH3-domain GRB2-like (endophilin) interacting protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118473:
SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:102741297-102973628

Strand

Forward strand

Band

Transcripts

ENSMUST00000097948	ENSMUSP00000095560
ENSMUST00000066824	ENSMUSP00000063712
ENSMUST00000072481	ENSMUSP00000072301
ENSMUST00000080728	ENSMUSP00000079553
ENSMUST00000106882	ENSMUSP00000102495
ENSMUST00000142430
ENSMUST00000137592
ENSMUST00000156596	ENSMUSP00000115075
ENSMUST00000136164
ENSMUST00000140289
ENSMUST00000149547	ENSMUSP00000122556
ENSMUST00000131431
ENSMUST00000141624
ENSMUST00000140676
ENSMUST00000183855	ENSMUSP00000139337

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0017124	SH3 domain binding

Biological Process

GO:0002021	response to dietary excess
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0016192	vesicle-mediated transport
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0097320	membrane tubulation
GO:2000253	positive regulation of feeding behavior
GO:2000507	positive regulation of energy homeostasis

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0030122	AP-2 adaptor complex
GO:0030131	clathrin adaptor complex
GO:0030136	clathrin-coated vesicle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000118473

View Gene Order

ENSBTAG00000011091

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.238094 Mm.402787 Mm.404525 Mm.418464 Mm.446273

RefSeq

NM_001285859 NM_001285860 NM_144906 XM_006503428 XM_006503429

OMIM

CCDS

CCDS18404 CCDS71429 CCDS71430

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas