InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp8a1

Summary

InnateDB Protein

IDBP-168129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp8a1

Protein Name

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

Synonyms

AI481521; AI853962; APLT; Atp3a2; AW743152; AW822227; B230107D19Rik; ClassI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072738

InnateDB Gene

IDBG-168125 (Atp8a1)

Protein Structure

UniProt Annotation

Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells; the activity is associated with hippocampus-dependent learning. {ECO:0000269PubMed:16618126, ECO:0000269PubMed:20224745, ECO:0000269PubMed:22007859, ECO:0000269PubMed:23269685}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Cell membrane {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures (By similarity). Localizes to plasma membranes of red blood cells. {ECO:0000250, ECO:0000269PubMed:16643453}.

Disease Associations

Tissue Specificity

Found in most tissues except liver and testis. Most abundant in brain and lung. Also detected in fetal tissues. Isoform 1 is expressed in brain. Isoform 2 and isoform 3 are expressed in reticulocytes. {ECO:0000269PubMed:16643453}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004012	phospholipid-translocating ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006812	cation transport
GO:0007612	learning
GO:0008152	metabolic process
GO:0015914	phospholipid transport
GO:0030335	positive regulation of cell migration
GO:0045332	phospholipid translocation
GO:0061092	positive regulation of phospholipid translocation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0042584	chromaffin granule membrane

Protein Structure and Domains

PDB ID

MGI:1330848

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR006539 Cation-transporting P-type ATPase, subfamily IV
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70704