InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zeb2

Summary

InnateDB Protein

IDBP-168226.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zeb2

Protein Name

zinc finger E-box binding homeobox 2

Synonyms

9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b; Zfx1b; Zfxh1b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076111

InnateDB Gene

IDBG-168224 (Zeb2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	4 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0070412	R-SMAD binding

Biological Process

GO:0001755	neural crest cell migration
GO:0001756	somitogenesis
GO:0001843	neural tube closure
GO:0006355	regulation of transcription, DNA-templated
GO:0007417	central nervous system development
GO:0021766	hippocampus development
GO:0021846	cell proliferation in forebrain
GO:0030177	positive regulation of Wnt signaling pathway
GO:0043507	positive regulation of JUN kinase activity
GO:0048598	embryonic morphogenesis

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1344407

InterPro

IPR001356 Homeobox domain
IPR007087 Zinc finger, C2H2
IPR009057 Homeodomain-like
IPR015880 Zinc finger, C2H2-like

PFAM

PF00046
PF00096

PRINTS

PIRSF

SMART

SM00389
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q8BSG9

UniProt Splice Variant

Entrez Gene

24136

UniGene

Mm.468060

RefSeq

MGI ID

MGI Symbol

Zeb2

OMIM

CCDS

HPRD

IMGT

EMBL

AK032970 AL929120 AL935127

GenPept

BAC28104